Publications

2024

Kikuchi M, Viet J, Nagata K, Sato M, David G, Audic Y, Silverman MA, Yamamoto M, Akatsu H, Hashizume Y, Chiba K, Takeda S, Akamine S, Miyamoto T, Uozumi R, Gotoh S, Mori K, Manabu Ikeda M, Paillard L, Morihara T. Gene-gene functional relationships in Alzheimer’s disease: CELF1 regulates KLC1 alternative splicing, In press, BBA - Molecular Basis of Disease

2023

Axonal transport of lysosomes is unaffected in glucocerebrosidase-inhibited iPSC-derived forebrain neurons. Keefe, AJ, Gabrych DR, Zhu Y, Vocadlo DJ, Silverman MA, 2023 Oct 1010(10)

2021

Intranasal Paclitaxel Alters Alzheimer's Disease Phenotypic Features in 3xTg-AD Mice. Cross, DJ, Huber, BR, Silverman, MA , MM, Gill TB, Cross CG, Cook DG , Minoshima S. J Alzheimers Dis. 202183(1):379-394.

2020

GSK3β Impairs KIF1A Transport in a Cellular Model of Alzheimer’s Disease but Does Not Regulate Motor Motility at S402​. Gan KJ, Akram A, Blasius EM, Budaitis BG, Gabrych DR, Verhey KJ and Silverman MA. eNeuro. 2020 Nov 5:7(6).

2019
Going Too Far Is the Same as Falling Short†: Kinesin-3 Family Members in Hereditary Spastic Paraplegia. Gabrych DR, Lau VZ, Niwa S and Silverman MA. Front Cell Neurosci. 2019 Sept 13:419.

2018
A catalytic antioxidant for limiting amyloid beta peptide aggregation and reactive oxygen species generation. Gomes LMF, Mahammed A, Prosser KE, Smith JR, Silverman MA, Walsby CJ, Gross Z and Storr T. Chemical Science. 2018 Dec 310(6):1634-1643.

In vivo induction of membrane damage by β-amyloid peptide oligomers. Julien C, Tomberlin C, Roberts CM, Akram A, Stein GH, Silverman MA and Link CD. Acta Neuropathol Commun. 2018 Nov 296(1):131.

Pharmacological inhibition of O-GlcNAcase (OGA) enhances autophagy in brain through an mTOR-independent pathway. Zhu Y, Shan X, Safarpour F, Go NE, Li N, Shan A, Huang MC, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman MA and Vocadlo DJ. ACS Chemical Neuroscience. 2018 Feb 9(6):1366-1379.

2016
Stochastic Subcellular Organization of Dense-Core Vesicles Revealed by Point Pattern Analysis. Robinson BJ, Stanisavljevic B, Silverman MA and Scalettar BA. Biophysical Journal. 2016 Aug 23111(4):852-63.

Imaging organelle transport in primary hippocampal neurons treated with amyloid-β oligomers. Gan KJ and Silverman MA. Methods in Cell Biology: Neuronal Cells. 2016 131:425-51.

2015

Mycalolide B dissociates dynactin and abolishes retrograde axonal transport of dense-core vesicles. Cavolo SL, Zhou C, Ketcham SA, Suzuki MM, Ukalovic K, Silverman MA, Schroer TA and Levitan ES. Mol Biol Cell. 2015 Jul 1526(14):2664-72.

Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons. Gan KJ and Silverman MA. Mol Biol Cell. 2015 Mar 1526(6):1058-71. (Highlighted article for this issue and selected for journal cover)

Modulation of neuronal insulin signaling rescues tau independent axonal transport defects in amyloid-β oligomer treated hippocampal neurons. Takach O, Gill TB and Silverman MA. Neurobiol Aging. 2015 Mar 36(3):1378-82.

Atlas stumbled: Kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption. Gan KJ, Morihara T and Silverman MA. Bioessays. 2015 Feb 37(2):131-41.

2014
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice. Yuzwa SA, Shan X, Jones BA, Zhao G, Woodward ML, Li X, Zhu Y, McEachern EJ, Silverman MA, Watson NV, Gong CX and Vocadlo DJ. Mol Neurodegener. 2014 Oct 269(1):42.

Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid beta accumulation modifier. Morihara T, Hayashia N, Yokokojia M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagamia S, Kazui H, Kudoa T, Hashimoto R, Itoh N, Nishitomi K, Kabata-Yamagichi Y, Tsunodah T, Takamurai H, Katayama T, Kimura R, Kamino K, Hashizume Y and Takeda M. Proc Natl Acad Sci USA. 2014 Feb 18111(7):2638-43.

2013
Activity dependent secretion of progranulin from synapses. Petoukhov E, Fernando S, Shivji F, Hunter D, Krieger C, Silverman MA and Bamji SX. J Cell Sci. 2013 Dec 126 :5412-21.

Amyloid-beta oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. Ramser EM, Gan KJ, Decker H, Fan EY, Suzuki MM, Ferreira ST and Silverman MA. Mol Biol Cell. 2013 Aug 24(16): 2494-505.

A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice. Heydet D, Chen LX, Larter CZ, Inglis C, Silverman MA, Farrell GC and Leroux MR. Dev Neurobiol. 2013 Jan 73(1):1-13.

2012

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers. Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST and De Felice FG. J Clin Invest. 2012 Apr 122(4):1339-53.

2011

A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo. Fonte V, Dostal V, Roberts CM, Gonzales P, Lacor P, Magrane J, Dingwell N, Fan EY, Silverman MA, Stein GH and Link CD. Mol Neurodegener. 2011 Aug 6(1):61.

KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons. Lo KY, Kuzmin A, Unger SM, Petersen JD and Silverman MA. Neurosci Lett. 2011 Mar 491(3):168-73.

2010

Expression of kinesin superfamily genes in cultured hippocampal neurons. Silverman MA*, Kaech S*, E. M. Ramser, Lu X, Lasarev MR, Nagalla S and Banker G (* equal authorship). Cytoskeleton. 2010 Dec 67(12):784-95.

Amyloid-β peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3β in primary cultured hippocampal neurons. Decker H, Lo KY, Unger SM, Ferreira ST and Silverman MA. J Neurosci. 2010 Jul 730(27):9166-71.

2009

Dynactin regulates bidirectional transport of dense-core vesicles in the axon and dendrites of cultured hippocampal neurons. Kwinter DM, Lo K, Mafi P and Silverman MA. Neuroscience. 2009 Sep 162(4):1001-10

Live imaging of dense-core vesicles in primary cultured hippocampal neurons. Kwinter DM and Silverman MA. J Vis Exp. 2009 May (27):1144.

Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia. Silverman MA and Leroux MR. Trends Cell Biol. 2009 Jul 19(7):306-16.

2008

The beta amyloid peptide can act as a modular aggregation domain. Link CD, Fonte V, Roberts CM, Hiester B, Silverman MA and Stein GH. Neurobiol Dis. 2008 Dec 32(3):420-5.

2006

Conversion of Green Fluorescent Protein into a Toxic, Aggregation-prone Protein by C-terminal Addition of a Short Peptide. Link CD, Fonte V, Hiester B, Yerg J, Ferguson J, Csontos S, Silverman MA, and Stein GH. J Biol Chem. 2006 Jan 281(3):1808-16.

2005

Activity-Dependent Release of Tissue Plasminogen Activator from the Dendritic Spines of Hippocampal Neurons Revealed by Live-Cell Imaging. Lochner JE, Honigman LS, Grant WF, Gessford SK, Hansen AB, Silverman MA and Scalettar BA. J Neurobiol. 2005 Nov 66(6):564-77.

A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons.
Rosales CR, Osborne KO, Scheiffele P and Silverman MA. Eur J of Neurosci. 2005 Nov 22(9):2381-86.

Motifs that mediate dendritic targeting in hippocampal neurons: a comparison with basolateral targeting signals. Silverman MA*, Peck R*, Glover G, He C, Carlin C and Banker G (* equal authorship). Mol Cell Neurosci. 2005 Jun 29(2):173-180.

Mechanisms of transport and exocytosis for dense-core granules containing tissue plasminogen activator in hippocampal neurons. Silverman MA, Johnson S, Gurkins D, Farmer M, Rosa P, Lochner J and Scalettar BG. J Neurosci. 2005 Mar 25(12):3095-106

2002

Regulation of peptidergic vesicle mobility by secretagogues. Washburn CL, Bean JE, Silverman MA, Pellegrino MJ, Yates PA and Allen RG. Traffic. 2002 Nov 3(11):801-9.
2001Sorting and directed transport of membrane proteins during the development of hippocampal neurons in culture. Silverman MA, Kaech S, Jareb M, Burack MA, Vogt L, Sonderegger P and Banker G. Proc Natl Acad Sci USA. 2001 Jun 98(13):7051-57.

2000

Vesicle transport in neurons, GFP in Motion II Video Contribution, Volume 2. Silverman MA, Kaech S, Burack M A and Banker G. Trends in Cell Biology. 2000.

The role of selective transport in neuronal protein sorting. Burack MA, Silverman MA and Banker G. Neuron. 2000 May 26(2):465-472.

1999

CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase. Silverman MA, Bernard O, Jaaro H, Rattner A, Citri Y and Seger R. J Biol Chem. 1999 Jan 274(5):2631-36.

1998

Evidence for involvement of extensive gene induction in multiple mechanisms of plasticity. Hevroni D, Rattner A, Bundman M, Lederfein D, Gbarah A, Mangelus M, Silverman MA, Kedar H, Naor K, Kornuc M, Theill L, Nedivi E and Citri Y. J Cell Mol Neurosci. 1998 10:75-98.

1997
Biochemical Analysis of Caenorhabditis elegans lectin-binding mutants. Silverman MA, Blaxter ML and Link CD. J Nematology. 1997 29(3):296-305.

1992

Characterization of Caenorhabditis elegans Lectin - Binding Mutants. Link CD, Silverman MA, Breen M, Watt KE and Dames SA. Genetics. 1992 131(4): 867-81.