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Pharmacological inhibition of O-GlcNAcase (OGA) enhances autophagy in brain through an mTOR-independent pathway by Zhu Y, Shan X, Safarpour F, Go NE, Li N, Shan A, Huang MC, Deen M, Holicek V, Ashmus R, Madden Z, Gorski S, Silverman MA, Vocadlo DJ. ACS Chemical Neuroscience. 2018, 9, 1366-1379
Stochastic Subcellular Organization of Dense-Core Vesicles Revealed by Point Pattern Analysis. Robinson BJ, Stanisavljevic B, Silverman MA, Scalettar BA. Biophysical Journal. 2016 Aug 23;111(4):852-63.
Imaging organelle transport in primary hippocampal neurons treated with amyloid-β oligomers. Gan KJ and Silverman MA. Methods in Cell Biology: Neuronal Cells. Cambridge: Elsevier. 2016;131:425-51
Mycalolide B dissociates dynactin and abolishes retrograde axonal transport of dense-core vesicles. Cavolo SL, Zhou C, Ketcham SA, Suzuki MM, Ukalovic K, Silverman MA, Schroer TA, Levitan ES. Molecular Biology of the Cell. 2015 Jul 15;26(14):2664-72.
Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer-treated hippocampal neurons. Gan KJ and Silverman MA. Molecular Biology of the Cell, 2015 Mar 15;26(6):1058-71. (Highlighted article for this issue and selected for journal cover)
Modulation of neuronal insulin signaling rescues tau independent axonal transport defects in amyloid-β oligomer treated hippocampal neurons. Takach O, Gill TB, Silverman MA. Neurobiology of Aging, 36, 2015, pp. 1378-1382
Atlas stumbled: Kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption. Gan, KJ, Morihara, T, and Silverman, MA. Bioessays. 2015 Feb;37(2):131-41
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice. Yuzwa SA, Shan X, Jones BA, Zhao G, Woodward ML, Li X, Zhu Y, McEachern EJ, Silverman MA, Watson NV, Gong CX, Vocadlo DJ. Molecular Neurodegeneration. 2014 Oct 26;9(1):42
Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid beta accumulation modifier. Morihara T, Hayashia N, Yokokojia M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagamia S, Kazui H, Kudoa T, Hashimoto R, Itoh N, Nishitomi K, Kabata-Yamagichi Y, Tsunodah T, Takamurai H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M. Proceedings of the National Academy of Sciences, 2014 Feb 18;111(7):2638-43.
Activity dependent secretion of progranulin from synapses. Petoukhov E, Fernando S, Shivji F, Hunter D, Krieger C, Silverman MA, and Bamji SX. J. Cell Science, 2013 Dec 1;126 :5412-21.
Amyloid-b oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons. Ramser EM, Gan KJ, Decker H, Fan EY, Suzuki MM, Ferreira ST, and Silverman MA. Mol Biol Cell. 2013 August 24;24(16): 2494-505.
A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice. Heydet D, Chen LX, Larter CZ, Inglis C, Silverman MA, Farrell GC, Leroux MR. Dev Neurobiol. 2013 Jan;73(1):1-13.
TR Bomfim, L Forny-Germano, LB Sathler, J Brito- Moreira, JC Houzel, H Decker, MA Silverman, H Kazi, HM Melo, PL McClean, C Holscher, SE Arnold, K Talbot, WL Klein, DP Munoz, ST Ferreira and FG De Felice.. Anti-diabetic drugs protect the brain from defective insulin signaling caused by Alzheimers toxic A oligomers. J Clinical Investigation. 2012 Apr 2;122(4):1339-53.
Fonte V, Dostal V, Roberts CM, Gonzales P, Lacor P, Magrane J, Dingwell N, Fan EY, Silverman MA, Stein GH, Link CD.. A glycine zipper motif mediates the formation of toxic -amyloid oligomers in vitro and in vivo. Molecular Neurodegeneration. 2011 Aug 23;6(1):61.
Lo, K.Y. , Kuzmin A. , Unger, S. M., Petersen, J.D., and Silverman, M.A.. KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons. Neuroscience Letters. 2011 Mar 24;491(3):168-73.
Silverman MA*, Kaech S*, E. M. Ramser, Lu X, Lasarev MR, Nagalla S, and Banker G, (* equal authorship) Expression of kinesin superfamily genes in cultured hippocampal neurons. Cytoskeleton, 2010 Dec; 67(12):784-95.
Decker H, Lo KY, Unger SM, Ferreira ST, Silverman MA. A oligomers disrupt axonal transport via an N-methyl-D-aspartate receptor-dependent mechanism in primary cultured hippocampal neurons. Journal of Neuroscience. 2010 Jul 7;30(27):9166-71.
Dynactin regulates bidirectional transport of dense-core vesicles in the axon and dendrites of cultured hippocampal neurons. Kwinter DM, Lo K, Mafi P, Silverman MA. Neuroscience. 2009 Sep 15;162(4):1001-10
16 Live imaging of dense-core vesicles in primary cultured hippocampal neurons. David Kwinter and Michael Silverman, Journal of Visualized Experiments. 2009 May 29; (27).
Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia. Silverman MA, Leroux MR. Trends in Cell Biology. 2009 Jul;19(7):306-16.
The beta amyloid peptide can act as a modular aggregation domain. Link CD, Fonte V, Roberts CM, Hiester B, Silverman MA, Stein GH. Neurobiol Dis. 2008 Dec;32(3):420-5.
Christopher D. Link, Virginia Fonte, Brian Hiester, John Yerg, Jmil Ferguson, Susan Csontos, Michael A. Silverman, and Gretchen H. Stein. Conversion of Green Fluorescent Protein into a Toxic, Aggregation-prone Protein by C-terminal Addition of a Short Peptide. THE JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 281, NO. 3, pp. 18081816, January 20, 2006.
Janis E. Lochner, Leah S. Honigman, Wilmon F. Grant, Sarah K. Gessford,Alexis B. Hansen, Michael A. Silverman, and Bethe A. Scalettar. Activity-Dependent Release of Tissue Plasminogen Activator from the Dendritic Spines of Hippocampal Neurons Revealed by Live-Cell Imaging. Journal of Neurobiology. November 2005
Rosales, C. R., Osborne, K. O., Scheiffele, P., and M. A. Silverman. A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons. European Journal of Neuroscience. Vol. 22, pp. 23812386, 2005
Silverman, M. A.,* Peck, R*. Glover, G. He, C., Carlin, C., and G. Banker, (* equal authorship). Motifs that mediate dendritic targeting in hippocampal neurons: a comparison with basolateral targeting signals. (2005) Molecular and Cellular Neuroscience. Jun;29(2):173-180.
Silverman, M. A., Johnson, S. Gurkins, D. Farmer, M. Rosa, P. Lochner, J., and Scalettar, B. G. Mechanisms of transport and exocytosis for dense-core granules containing tissue plasminogen activator in hippocampal neurons. (2005) J. of Neuroscience. March 23;25(12):3095-106
Washburn C.L., Bean J.E., Silverman M.A., Pellegrino M.J., Yates P.A., Allen R.G. Regulation of peptidergic vesicle mobility by secretagogues. (2002). Traffic. Nov;3(11):801-9.
Silverman, M. A., Kaech, S., Jareb, M., Burack, M. A., Vogt, L., Sonderegger, P., Banker, G. (2001). Sorting and directed transport of membrane proteins during the development of hippocampal neurons in culture. Proceedings of the National Academy of Sciences. June 19; 98 (13): 7051-7057
6 Silverman, M. A., Kaech, S., Burack, M. A., Banker, G. (2000). Vesicle transport in neurons. GFP in Motion II CD-ROM, Volume 2. Trends in Cell Biology.
Burack, M. A., Silverman, M. A., Banker, G. (2000). The role of selective transport in neuronal protein sorting. Neuron. 26(2): 465-472.
Silverman, M.A., Bernard, O., Jaaro, H., Rattner, A., Citri, Y., Seger, R. (1999). CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase J. of Biological Chemistry. 274(5): 2631-2636.
3 Hevroni, D., Rattner, A., Bundman, M., Lederfein, D., Gbarah, A., Mangelus, M., Silverman, M. A., Kedar, H., Naor, K., Kornuc, M., Theill, L., Nedivi, E., Citri, Y. (1998). Evidence for involvement of extensive gene induction in multiple mechanisms of plasticity J. of Cellular and Molecular Neuroscience. 10: 75-98.
2 Silverman, M.A., Blaxter, M.L., Link, C.D. (1997). Biochemical Analysis of Caenorhabditis elegans lectin-binding mutants. J. of Nematology. 29(3):296-305 1997.
1 Link, C. D., Silverman, M.A., Breen, M., Watt, K.E., Dames, S.A. (1992). Characterization of Caenorhabditis elegans Lectin - Binding Mutants. Genetics 131: 867-881.